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Remove air bubbles by tapping the syringe and gently pushing the plunger until a small droplet appears at the needle tip

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It is the best option for researchers who prioritize rapid onset, brain delivery, or needle-free administration and are willing to accept lower bioavailability and more frequent dosing

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[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Stanley B.G., Urstadt K.R., Charles J.R., Kee T