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Patient reports and clinical observations suggest that some individuals do experience muscle cramps while taking GLP-1 medications, though establishing direct causation remains challenging

In SELECT, semaglutide 2.4 mg subcutaneously weekly reduced MACE by 20% (HR 0.80, 95% CI 0.720.90) with a 1.5% absolute risk reduction over a mean follow-up of 39.8 months [3]

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Adverse effects such as nausea, vomiting, and gastrointestinal discomfort remain common, but usually diminish with time and proper dose escalation

Improved Metabolic Health and Inflammation Balance Semaglutide has been shown to improve insulin resistance and metabolic markers