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What we call clinical trials testing, what we call phase one, phase two, phase three, where effectively the medicine, in this case, the vaccine is tested in human volunteers and subjects which are representative of the population of people you're going to be giving the vaccine to

Pflgers Archiv 1995;430:381-388 106

A separate, possibly complementary mechanism involves iron sequestration

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these can present with neonatal hepatitis, fat malabsorption, or neurologic defects that can progress to chronic liver disease or liver failure and death