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The authors suggest that sustained weight loss may therefore require ongoing therapy in some patients

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The appetite suppression that feels dramatic in the early weeks tends to diminish over months as the body adapts

Why People Regain Weight After Discontinuing GLP-1 Treatment GLP-1 medications suppress appetite by activating receptors in your hypothalamusthe part of your brain that controls hunger

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But the pause brought renewed attention to one of the biggest challenges in health care today, one that played a role in GICs woes: the high price of popular GLP-1 drugs to treat obesity