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These include mutations in genes such as: SNCA Alpha-synuclein gene PRKN Parkin RBR E3 Ubiquitin Protein Ligase PINK1 Gene PARK6 DJ-1 and PARK7 Gene LRRK2 It is believed that mutations in these genes can cause dysfunction and eventual death of dopamine-producing neurons through various mechanisms, including protein aggregation, mitochondrial dysfunction, and oxidative stress

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