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We cover these topics in greater detail: Vasomotor symptoms such as flushing and night sweats are the most commonly reported symptom of the menopause, occurring in up to 80% of women

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Sleep disturbances have a negative impact on the signaling pathways that regulate structural and synaptic plasticity, such as those involving cyclic adenosine monophosphate (cAMP), glutamatergic signaling, mammalian target of rapamycin (mTOR), protein synthesis, and transcriptional mechanisms

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Research also demonstrates effects on other neurotrophins including Nerve Growth Factor (NGF) and GDNF (Glial cell line-Derived Neurotrophic Factor)

It may also regulate melanin production by the release of the -melanocyte stimulating hormone and the precipitation of zinc-2-glycoprotein in tissues