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Amylin vs GIP/GLP-1 dual agonists (tirzepatide) Tirzepatide (Mounjaro/Zepbound): Dual GIP + GLP-1 receptor agonist Single molecule, two pathways 15-22% weight loss monotherapy FDA approved Superior to semaglutide alone Tirzepatide vs cagrilintide monotherapy: Theoretical tirzepatide + cagrilintide combination: Would add amylin pathway to GIP/GLP-1 Three pathways total Potential 20-30% weight loss But no clinical data (unstudied) Very high GI side effect risk CagriSema (sema + cagri) safer, proven choice See our cagrilintide dosage with tirzepatide analysis

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One thing that does seem to be clear is that staying on the drug is important if heart health is a treatment goal

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