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Unlike traditional weight loss medications that often target a single pathway, cagrilintide acts as a dual agonist, primarily affecting both the amylin receptor and, in some cases, the calcitonin receptor

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Brain activity profiling of GLP-1MK-801 Encouraged by the transcriptomic data indicating that the weight loss is evoked through a mechanism of action involving the combined pharmacological actions of NMDA receptor antagonism and GLP-1 receptor agonism in the hypothalamus, we performed a comprehensive comparison between GLP-1MK-801 and the long-acting GLP-1 receptor agonist, semaglutide