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Conservative therapy cannot get rid of the obstructions, which makes Meibomian gland probing (MGP) medically appropriate

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AD associated neuroinflammation can also activate the kynurenine pathway, diverting metabolism of tryptophan away from serotonin towards production of neurotoxic metabolites (see Neuroinflammation section) [70]

Importantly, CSVD frequently coexists with Alzheimers disease pathology and contributes substantially to mixed dementia syndromes

C-X-C motif chemokine ligand (CXCL), a typical chemokine, can recruit immune cells to infiltrate the cerebrovascular system and brain parenchyma before initiating a variety of pathways leading to neuronal death (67)

This dual activation of PPP and glutaminolysis not only fuels mitochondrial respiration but also sustains proliferation, conferring a growth advantage tightly linked to NOTCH1 mutational status and consistent with the transcriptomic signature