After supplementation with DHO or OA (the substrate and product of DHODH), the ferroptosis caused by GPX4 inhibition was attenuated and enhanced, respectively, and these effects were particularly significant in cancer cells with low GPX4 expression
Both kidney-type glutaminase (GLS1) and liver-type glutaminase (GLS2) have been shown to act as tumor suppressors in some conditions (8)
doi:10.1530/EJE-14-0147 Fasano A
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