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By the same time, the FDA approved the use of a equimolar combination of IGF-1 and IGFBP-3 (Mecasermin Rinfabate, iPlex), suggesting that it would be a better choice, seeming as it will require lower doses because of the augmented half-life of the molecule and buffering effect on concentration

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That difference is important because it reframes expectations and treatment goals

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B12 is especially beneficial for individuals who have difficulty absorbing B12 from food or oral supplements, which can occur due to certain digestive disorders, age-related changes, or specific medical conditions

Debourdeau, S