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Depletion of TrkB signalling in iSPNs impairs their inhibitory function, leading to spontaneous hyperactivity in Trkb Penk -KO mice with increasing age 13

A slightly opposing study, however, was reported no immunological benefit of selenium in patients with moderate disease activity (in terms of TPOAb and cytokine production patterns) may not (equally) benefit as patients with high disease activity (108.3)

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Bochem A, van Capelleveen J, Dallinga-Thie G, Schimmel A, Motazacker M, Tietjen I, Singaraja R, Hayden M, Kastelein J, Stroes E, Hovingh G