Semaglutide is a GLP-1 receptor agonist used in several prescription medicines for type 2 diabetes and, under specific labeling, chronic weight management
At Cape Fear Physical Medicine and Rehab, we are committed to helping individuals improve their health, manage chronic conditions, and achieve sustainable weight loss
Patients should contact their GP or prescribing clinician if they experience any of the following: Severe or worsening fatigue that: Persists despite implementing lifestyle modifications Progressively worsens rather than improving over time Significantly impairs daily functioning, work performance, or quality of life Is accompanied by weakness, dizziness, or fainting episodes Associated symptoms suggesting potential complications: Severe, persistent abdominal pain, possibly radiating to the back, with or without vomiting (potential signs of pancreatitis requiring urgent medical attention) Pain in the right upper abdomen, fever, or jaundice (potential signs of gallbladder disease) Persistent nausea, vomiting, or diarrhoea leading to dehydration Signs of dehydration: dark urine, dry mouth, reduced urine output, confusion Rapid or irregular heartbeat, chest pain, or shortness of breath Unexplained weight loss exceeding recommended targets (faster than about 0.5-1 kg per week) Mood changes, depression, or anxiety Yellowing of skin or eyes, dark urine, or pale stools (potential liver concerns) For patients with diabetes, particularly those taking insulin or sulfonylureas, symptoms of hypoglycaemia (sweating, shakiness, confusion, irritability) alongside fatigue require prompt attention and potential medication adjustment
Semaglutide (GLP-1 mono-agonist) typically delivers around 14.9% loss at 68 weeks in STEP 1, against roughly 22.5% for tirzepatide 15 mg in SURMOUNT-1 [4]
This article examines the evidence, risk factors, and practical guidance for managing hypoglycaemia risk in patients prescribed Rybelsus
How effective is Tirzepatide for weight loss, and what results can I expect before and after treatment
