Very little is understood about the metabolic effects that thiazides, thiazide-like and loop diuretics may have in hepatic glucose production and/or degradation
There's also a peptide called GIP (glucose-dependent insulinotropic polypeptide), a 42-amino-acid hormone secreted by the small intestine that makes insulin more efficient and works as an appetite suppression booster alongside GLP-1
"You won't look or feel better, and you are very likely to end up injured, dead, out of money or all the above." Your health and safety come first
Cytotoxicity of Benzo[c]phenanthridinium Alkaloids in Isolated Rat Hepatocytes
493 During the treatment of patients with moderate to severe UC, persistent intestinal emergencies improve and are relieved, rectal bleeding is significantly reduced, 494,495,496 and C-reactive protein and fecal calprotectin levels decrease to varying degrees
Some individuals report benefits within the first few weeks, while others require 8-12 weeks to notice substantial improvements