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Primary risks include additive cardiovascular effects (increased heart rate and blood pressure), intensified gastrointestinal symptoms (nausea, vomiting, diarrhea), and potential for serious adverse events including pancreatitis and acute kidney injury requiring close monitoring

Gastroenterology S0016-5085(16)00219-5

As an anti-inflammatory agent this may also reduce oxidative damage to tissues

Other applications include support for erectile function, sexual performance, and post-exercise recovery

3,4 In our practice, we recommend endoscopic evaluation for patients over age 40 with rectal bleeding, especially if they have a family history of colorectal cancer

But one of the most challenging parts of my clinical career has been finding products that my patients can tolerate