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However, dangerous levels of methemoglobinemia only occur in patients with G6PDH deficiency and, thus, this drug should not be administered to anyone with a deficiency of this enzyme

Even low-grade leakage of endotoxin (LPS) from the gut can trigger chronic neuroinflammation: LPS in the bloodstream has been shown to activate microglia in the brain via TLR4/NF-B signaling, thereby contributing to neuronal injury [37]

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