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Because the ambient temperature is lower, longer sessions are appropriate

It directly neutralizes reactive oxygen and nitrogen species, regenerates the oxidized forms of vitamin C and vitamin E (restoring their antioxidant activity), and serves as a cofactor for glutathione peroxidase enzymes that reduce hydrogen peroxide and lipid peroxides

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The most frequently used treatments have been for long topical corticosteroids, topical calcineurin inhibitors (TCIs), and phototherapy (Zubair and Hamzavi, 2020

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