Astuto, F
DPP-4 inhibitors, the active comparator employed, are not biologically inert: by inhibiting dipeptidyl peptidase-4, they increase endogenous GLP-1 bioavailability, which may attenuate or confound the apparent advantage conferred by exogenous GLP-1 RA therapy
This group includes people with atypical anorexia, who have anorexia nervosa symptoms including distorted body image, intense fear of weight gain, and restrictive eating patterns but are of average or above average weight
Recent research has shown that GLP-1 receptor agonists can also promote weight loss, reduce appetite, improve cardiovascular outcomes, and potentially modulate the immune system
Overall, the genes most highly modulated by SR4 were primarily associated with fatty acid synthesis, lipid accumulation and liver steatosis, inflammatory responses and fibrotic processes, which suggested that SR4 may exert protective effects through the coordinated regulation of hepatic metabolic and stress-response pathways
A responsible reading of the distinct functions conclusion has to foreground its limitations, because they are large enough to change how much weight the conclusion can bear
