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Journal of Clinical Investigation, 103(1), 1928

The marked difference between gray matter versus white matter GSH absolute value increase is congruent with findings in prior literature and the proposed mechanisms that the brain response to the ketogenic diet is mainly at a cellular level located within the mitochondria of the gray matter

At the end of this 7-day labelling period ( t = 0 h), samples were collected to verify complete incorporation of the heavy label into cellular proteins

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Dosing guidance instead comes from clinical trial precedent