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Answer: Reported tolerability of these peptides is generally favorable in the literature, but they are not FDA-approved drugs, long-term human safety data is limited, and use should always be medically supervised

Overall, studies of high-dose B vitamin supplements taken over long periods have not shown clear protective effects against cancer incidence or cancer deaths

Despite the lack of extra support for lifestyle modification as part of the SURPASS program, 4069% of patients achieved 10% weight loss with the highest doses of tirzepatide (1015 mg), which ranged from 9.5 kg to 12.9 kg [100]

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This is highly variable

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