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Downregulation of the p53 signaling pathway promotes cellular proliferation and modulates inflammatory responses 71 , while HDAC7 depletion facilitates cell migration, angiogenesis, and extracellular matrix remodeling, collectively contributing to coordinated tissue repair 72

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Conversely, if the glutathione production process (or the trans-sulfuration pathway) is not functioning properly, the process backs up and homocysteine levels accumulate putting additional strain on the methylation cycle to remove it

doi:10.1159/000455014 Weber, J.S., DAngelo, S.P., Minor, D., Hodi, F.S., Gutzmer, R., Neyns, B.,

It is concluded that the extent of dGSH adduct, representing that of reactive metabolites, formed by rat liver microsomes correlate well with hepatotoxicity profile of a compound