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doi: 10.1002/14651858.CD007506.pub3

However, persistent burning, stinging, or increasing irritation suggests the concentration may be too high or your skin needs more time to adjust

Notably, subjects carrying MC1R variant alleles who typically tan poorly and are at higher skin cancer risk showed a greater melanin response than those with wild-type MC1R (Fitzgerald et al., 2006)

Eur J Pharmacol 954:175896

This could undermine weight management goals and complicate diabetes control, particularly if increased food intake leads to higher caloric consumption or poor dietary choices

Researchers are finding evidence for cardiovascular, neuro-protective and potentially anti-inflammatory effects as well