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The wide range of synaptic deficits observed in ASD-associated SHANK3 rodent models are alterations in NMDARs [72]

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Nonetheless, melittins administration appears to have cytotoxic effects on normal human cells, potentially raising mRNA levels of oxidative stress and apoptosis-related genes (58)

The results revealed that the levels of pro-inflammatory cytokines IL-6, IL-12, and TNF- secreted by cells treated with NP4 were 1.45, 5, and 1.78 times higher than those secreted by cells treated with NP2, respectively, further confirming the activation of macrophages

The samples were acetone precipitated using pre-chilled (20 C) 6 volumes (~600 L) of acetone overnight

Conclusion The present study observed increased expression of amyloid plaques and NFT in the brain of rats those underwent aluminium exposure, which was coinciding with decreased locomotor activity confirming Al induced neurotoxicity