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and Tsushima, S., 2013

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The third major target is the selenoenzyme GPx4

These measurements allow the calculation of the ratio of GSH/GSSG, or the ratio of reduced to oxidized glutathione, in order to determine the oxidative stress present in cultured mammalian cells in response to a compound

Translation is limited at present by on-target injury in normal tissues and by off-target pathway perturbations, necessitating solutions that separate lesion efficacy from systemic risk

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