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Clinical trials of semaglutide for weight loss recorded injection-site reactions in a small percentage of participants, but bruising was not distinguished as a separate or frequent event

doi: 10.1161/ATVBAHA.117.310581 58 AnandPK

And third, both studies were done specifically in people with prediabetes, who already have disrupted blood sugar regulation

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Finally, studies published prior to 2018 were included only if they provided foundational pharmacokinetic or pharmacodynamic data on GLP-1 receptor distribution in the CNS or on the initial development of acylated GLP-1 analogs

Anxiety and mood effects, where they occur, tend to peak here