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doi: 10.1038/mp.2016.196 25 ChenJJGalluzziL

In bladder cancer, PD-L1 expression was observed to be upregulated via the EGFR/MEK/ERK/c-Jun pathway under conditions of glutamine deficiency, impairing T cell function [169]

In this review, the role of glutathione and glutathione-dependent enzymes in the maintenance of redox homeostasis is summarized

Glutathione might inhibit the effects of cerebral infarction and enhance antiapoptotic signaling after ischemic stroke, suggesting that GSH may be a potent therapeutic antioxidant that can attenuate severe pathologies after ischemic stroke, and stimulating GSH synthesis through administration of GSH precursors and micronutrients like selenium can optimize GSH and GSH peroxidase for optimal antioxidant defense in cerebral ischemia (155, 156)

However, some scientists have raised concerns about their sustained use ( Adding glutamine to a regular diet may cause a variety of changes in the way the body absorbs and processes amino acids

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