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This is why many researchers reconstitute only what they need for the near term and keep remaining powder in long-term storage

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These may include incomplete sequences, misfolded proteins, side-reaction compounds, or host cell proteinsall of which must be removed during purification

Additionally, the hydrophilic GOs preferentially interacted with LDL apolipoproteins, modulating their secondary conformation via electrostatic interactions and impairing LDLR binding domains

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