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Summary and discussion Nrf2 plays an important role in the regulation of ferroptosis, which exhibits a dual role in lung diseases by modulating ferroptosis [113]

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Mechanistically, confirming the bioinformatic prediction, palmatine downregulated the expression of the five key targets and concurrently suppressed the activation of critical apoptotic executers (Caspase-3, Caspase-8, GSDME)

Green JB, Bethel MA, Armstrong PW, et al