Some practitioners have considered it for the management of neuropathic pain, as well as in the adjunctive treatment of certain psychiatric conditions where vitamin B12 plays a supportive role in managing symptoms
However, berberine is not recommended as monotherapy for type 2 diabetes or obesity requiring significant metabolic intervention, and its effects plateau at modest levels
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[DOI] [PubMed] [Google Scholar] 78.Han E., Kim A., Lee S.J., Kim J.-Y., Kim J.H., Lee W.J., Lee B.-W
La depuracin de este frmaco disminuye significativamente en pacientes con enfermedad renal crnica en hemodilisis ya que su eliminacin es principalmente por filtracin glomerular, por lo que no est recomendada en pacientes con depuracin de creatinina 30 ml/min), pero debe monitorearse una posibilidad de mayor incidencia de efectos adversos gastrointestinales y renales, mientras que debido a la falta de datos en pacientes con enfermedad renal terminal, no se recomienda su uso 69,70