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10.1158/1535-7163.MCT-11-0942 92 KaurH.KumarB.ChakrabartiA.MedhiB.ModiM.RadotraB

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The specific objectives of this study include: 1) Evaluating the effect of DMSA therapy on children with ASD, including effect on excretion of toxic metals, excretion of essential minerals, level of glutathione, blood chemistry, complete blood count (CBC), and symptoms of autism

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Since mitochondrial metabolism is prevalent in normal high-energy-demand tissues, such as the heart and liver, OXPHOS inhibitors (e.g., IACS-010759) have shown dose-limiting toxicities (DLT) in some clinical trials, hindering their widespread application [173]

Furthermore, no mutagenic or genotoxic effects have been reported in standard tests