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Statistical analyses As Pearson correlation coefficients between the nine metabolite concentration values (three metabolites in three voxels) were substantial even after adjustment for potential confounders, we used principal component analysis (PCA) to identify latent metabolite variables, and extracted scores for each component (see Results and SA7 for details)

Metformin works by decreasing the amount of glucose (sugar) made by the liver and absorbed from food in the gut

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In this particular study, aortic regurgitation was found in 18 percent of the participants with ankylosing spondylitis

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