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Natriuresis [32], direct vasodilation [33], reductions in sympathetic nervous system activity [34], extracellular volume and midregional-pro-atrial natriuretic peptide (proANP) [33, 35] are potential direct mechanisms for GLP-1 RAs leading to SBP lowering

Semaglutide builds to steady-state concentrations more slowly than tirzepatide due to its longer half-life

Research showed that glucagon co-agonism increased hepatic fat oxidation and thermogenesis, providing an additional fat-loss mechanism distinct from appetite suppression alone

Levothyroxine absorption can be slightly affected by delayed gastric emptying