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The first is that isolated cells are not under systemic control by the whole organism, lacking factors such as the regulatory effects of endocrine and nervous systems, which may substantially modify cellular responses

10.1016/j.neuroscience.2014.11.045 Neuroscience 499 WangT

So you do have to be very careful

Apart from its hypoglycemic effects, metformin has been shown to have several other beneficial effects on lipid profile, immune and coagulation responses, and hormone synthesis (Musi et al., 2002