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The heterogeneity of type 1 diabetes: implications for pathogenesis, prevention, and treatment2024 Diabetes, Diabetes Care, and Diabetologia Expert Forum

Higher-order thiol cell system like metallothioneins, thioredoxins, and other redox regulator proteins are ultimately regulated by reduced form of Glutathione (GSH) levels and the ratio of GSH / GSSG (oxidized GSH)

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NNMT is an enzyme that converts nicotinamide to N-methylnicotinamide, consuming methyl groups and potentially reducing NAD+ availability