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However, this preservation of mitochondrial function creates a paradox: by maintaining the electron transport chain, CHAC1 inadvertently supplies the ROS that propagate iron-dependent lipid peroxidation (Gao et al., 2019)

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2019;241(1):R1R33

They effectively block acetylcholine (Ach) binding and overstimulate cells at synaptic junctions, obstructing nerve impulse propagation and leading to cell and/or individual paralysis and death (Almeida et al