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Some common symptoms of hypothyroidism include fatigue weight gain trouble tolerating cold joint and muscle pain dry skin or dry, thinning hair heavy or irregular menstrual periods or fertility problems slowed heart rate depression Because hypothyroidism develops slowly, you may not notice symptoms of the disease for months or even years

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While lifestyle changes remain essential, they are often not sufficient

10.1074/jbc.M109.063172 161 KoniorA.SchrammA.Czesnikiewicz-GuzikM.GuzikT