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Authors contributions Writing review & editing, writing original draft (HZ, DW, QW, YWu, ZG, LW, YWang, QZ, LS, BS, GY, WL), formal analysis (HZ), conceptualization (HZ, GY, WL), supervision, and funding acquisition (GY, WL)

Early evidence demonstrated that high levels of protein carbonyl groups, a general marker of OS, were present in both postmortem spinal cord [88, 89] and motor cortex [90] from sALS patients, compared to control samples

In contrast, this area is a positively charged flat surface in GPx4 (Figure 4c) and has been considered to be involved in the efficient binding of complex lipid molecules at the active site 21

We plan to perform sensitivity analyses to explore the effect of departures from the missing data assumptions made in the efficacy analyses