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Description

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In CRC, EZH2 suppresses the upstream mTOR inhibitors TSC2, RHOA, DEPTOR , and FKBP11 by recruiting MTA2 and increasing H3K27me3 at their promoters, thereby activating mTOR signaling and inhibiting autophagy

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Although its specific histone targets at ATG loci remain unclear, HDAC8 is implicated in maintaining a repressive chromatin state

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Daily doses of melatonin at 2.5 and 5 mg/kg were administered for a period of 2 months

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