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Trade-offs: Can cause morning grogginess, orthostatic hypotension, or REM alterations

It carries a C20 fatty-diacid acylation that enables strong albumin binding and a serum half-life of approximately 6 days, supporting the once-weekly administration cadence used in published Phase 2 research literature

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doi: 10.1016/j.jcjd.2019.09.003 110 HusainMBirkenfeldALDonsmarkMDunganKEliaschewitzFGFrancoDRet al