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Second, we integrate recent molecular evidence spanning both classical and emerging pathways in lipid metabolism (including AMPK, SIRT1, PPAR, and PGC1) as well as metabolicinflammatory signaling related to insulin resistance (e.g., activation of IGF-1/AKT and inhibition of NF-B)

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serious events remain rare in community reports at typical doses

Patients should be assessed individually to determine the most appropriate agent based on their clinical needs, treatment goals, and ability to adhere to the prescribed regimen

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