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2006 Jul;38(7):1288-96

Individuals with low levels of B12 may experience symptoms such as fatigue, insomnia, and changes in appetite, all of which can contribute to weight gain and poor sleep quality

Frequently Asked Questions Are B12 Shots Safe During Pregnancy

Niacin: A large increase in niacin dosage may cause fainting, as was recently reported

Most clinicians consider weight loss injections 6-12 months post-operatively after the initial rapid weight loss phase, or when patients experience a plateau or weight regain despite adherence to post-surgical recommendations

In practice, this combination would need to be evaluated by a supervising physician with careful monitoring