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We expect that an altered tongue microenvironment will result in a change of taste sensitivity as detected by chemical gustometry along with a changed neural response to visual food cues in reward processing regions as assessed by functional MRI

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Epub 2021 Oct 4

Tirzepatide, which acts on both GIP and GLP-1 receptors, appears to have a somewhat more favorable GI tolerability profile, possibly because GIP receptor activation partially counteracts the nausea-inducing effects of GLP-1 agonism