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Three research contexts recur in the literature

TRT may benefit men with low testosterone levels but might not be effective for those with normal or high testosterone levels

History of hormone-sensitive conditions As a precaution, until more human data is available

These insights highlight both the potential and the limitations of semaglutide as a pharmacological tool for weight management and metabolic health

The net effect depends on concentration, timing, and cellular environment

Data extraction Two researchers independently extracted the required data from the full-text articles, and conflicts were resolved through discussions with a third researcher