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Of these, 100 genes overlapped between treatments (Figure 1A)

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Overall, SIRT1 and AMPK occupy upstream positions in signaling cascades that mediate RES neuroprotective potential, while enzymes such as extracellular signal-regulated kinase 1/2 (ERK1/2), monoamine oxidase (MAO), and transcription factors and neurotrophins such as BDNF, CREB, Nrf-2, mammalian target of rapamycin (mTOR), Forkhead box O (FOXO), NF-B, and others are downstream targets [43]

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Gill PA, van Zelm MC, Muir JG, Gibson PR

NHAs: normal human astrocytes