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Prior work has reported that the enhanced insulin action in response to PSAT1 overexpression is mediated by decreased expression of tribbles homolog 3 (TRB3), which is a pseudokinase that inhibits insulin signaling by binding to Akt and impairing its activation by phosphorylation (26)

This condition is known as megaloblastic anemia, which reduces the bloods ability to carry oxygen and can result in fatigue, weakness, pale skin, and other symptoms

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