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Consider breaks: Long-term use may require tolerance-prevention cycles

These apply whether you are on AOD 9604, tirzepatide, or any other weight loss intervention

FDA.gov (2026) 12

Even those who eventually tolerate high concentrations well typically experience problems when starting there

Together these findings suggest that the elimination of senescent cells through vaccination targeting GPNMB-expressing cells could be beneficial to health span and possibly extend lifespan

The pattern is clear: promising preclinical research exists across many domains, but moving from animal models to demonstrated human benefit remains the central scientific challenge