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Supplementary information ESM 1 (download DOCX (DOCX 1210 kb) Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made

Note that the senior author is Wright, the principal investigator of the Harding laboratory

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We do not have clear, measurable results from human trials

It is commonly studied where peptide signaling, cytoskeletal activity, and cellular migration are evaluated together under conditions of mechanical stress or localized disruption