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Additionally, M2-like TAMs upregulate arginase 1 (Arg1), enhancing arginine metabolism and further depleting extracellular arginine, thereby exacerbating immunosuppression (93)

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Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis

By 2026, we're seeing advanced clinical trial data for drugs like Retatrutide (a 'tri-agonist') and others that promise different mechanisms and, potentially, different tolerability profiles