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The construction of all yeast strains is shown in Supplementary Table 5

If, for example, a malalignment is found as the cause and only part of the joint is affected (inner or outer side), a correction of the malalignment (osteotomy) can bring about an improvement in the symptoms and prevent or slow down further progression of the osteoarthritis

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These cell lines were then transplanted under the renal capsule of severely immunodeficient mice, and the xenografts were harvested five weeks after transplantation

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