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Cancer Cell 16(3):183194 Grenier A et al (2002) Presence of a mobilizable intracellular pool of hepatocyte growth factor in human polymorphonuclear neutrophils

Whereas the monomers and the protofilaments are harmless, the oligomers are cytotoxic and induce cell death in primary neuronal cells, fibroblasts, and neuroblastoma cells [69]

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More importantly, as will be discussed below, because the genome content tends to be highly conserved between bona fide carriage and disease isolates, subtle differences in the ability to modulate gene expression in host microenvironments, to engage in productive cross-talk with the cells also at metabolic level, to elude the host immune defenses, and to evolve over a short period of time have been proposed as major determinants of the hyperinvasive phenotype